After seven national bestsellers and eight seasons as one of the most successful shows on television, New York Times bestselling author Jeff Lindsay bids a thrilling farewell to his uniquely twisted and beloved serial killer, Dexter Morgan. Dexter Is Dead is the definitive conclusion of the character who has become a global icon.
Dexter Morgan has burned the candle at both ends for many years. Blood spatter analyst . . . husband . . . father . . . serial killer. And now, for the first time, his world has truly collapsed. Dexter is arrested on charges of murder. He has lost everything—including his wife, his kids, and the loyalty of his sister. Now completely alone, Dexter faces a murder charge (for a crime . . . ironically . . . he did not actually commit). His only chance for freedom lies with his brother, Brian, who has a dark plan to prove Dexter's innocence. But the stakes are deadly, and the epic showdown that lies in Dexter's path may lead, once and for all, to his demise.
Jeff Lindsay's trademark devilish wit and cutting satire have never been sharper. Dexter Is Dead marks the end of a beloved series, but is also Dexter's most satisfying and suspenseful outing yet. 
Dexter is accused of murdering Rita and molesting Astor. The Miami-Dade Police HQ does all they can to pin the crimes on Dexter, even resorting to falsifying evidence. Deborah decides to cut ties with Dexter and takes custody of his children. Only Vince Masuoka is working to clear Dexter's name, with no success. Brian bails Dexter out of jail and gets him a lawyer, but is being targeted by a Mexican drug cartel he had previously stolen money from. The cartel tries to kill Dexter multiple times to get to Brian.
Deborah reluctantly contacts Dexter to inform him his kids have been kidnapped, which leads to a fragile reconciliation. Dexter manages to set up a meeting with Detective Anderson and some of Raul's thugs to get him killed, which happens, though not before he manages to kill his attackers, leaving Dexter with no one to interrogate. Eventually, they find out that their lawyer was supplying Raul with Dexter's intel, which makes them ambush him, kill him and all the cartel's members who followed Frank, save for one, who is taken by the brothers to a secluded warehouse, where he is severely interrogated and mutilated to get the kids' location and to satisfy their urges.
Once Dexter's children are located, Brian, Deborah, and Dexter team up, break onto Raul's yacht, and take the kids back. Deborah takes the kids away, but Brian is killed by a bomb he himself planted and Dexter is severely wounded by it and a gunshot from Raul, followed by a stomp on his wound. After Deborah kills Raul, Dexter stays on the yacht to set another bomb so there's no evidence left. Deborah is too far away to help, and he can find no escape. Dexter laments his fate, the book ending with his final thought cut off, as the ship presumably explodes.